TM4SF4

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. [provided by RefSeq, Mar 2011]

Description

Transmembrane 4 L six family member 4

Tissue specificity

Group enriched (gallbladder, intestine, liver)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (149474697 - 149503394)

Ensembl ID

ENSG00000169903  (ver. 103.38)

Orthologs

Mouse Tm4sf4: ENSMUSG00000027801

UniProt

P48230

neXtProt

NX_P48230

Human splice variants
Mouse splice variants

Protein structure