ADRA1B

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Description

Adrenoceptor alpha 1B

Tissue specificity

Tissue enhanced (brain, liver, lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

5 (159865080 - 159973012)

Ensembl ID

ENSG00000170214  (ver. 103.38)

Orthologs

Mouse Adra1b: ENSMUSG00000050541

UniProt

P35368

neXtProt

NX_P35368

Human splice variants
Mouse splice variants

Protein structure