ACYP2

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Description

Acylphosphatase 2

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (53970838 - 54305300)

Ensembl ID

ENSG00000170634  (ver. 103.38)

Orthologs

Mouse Acyp2: ENSMUSG00000060923

UniProt

P14621

neXtProt

NX_P14621

Human splice variants
Mouse splice variants

Protein structure