Tissue expression
Cell line expression
Protein structure
POLH
DNA polymerase etaRAD30A, XP-V
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Top validated antibodies |
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GeneTex | GTX54545 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
LSBio | LS-C832109 | Polyclonal |
WB
EL
IHC
|
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Novus Biologicals | NB100-60424 | 2 references | Polyclonal |
WB
IP |
|
Invitrogen Antibodies | PA5-98071 | Polyclonal |
WB
EL
ICC
IHC |
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Cusabio Biotech Co., Ltd | CSB-PA018321LA01HU | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider