NUDT6

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Description

Nudix hydrolase 6

Tissue specificity

Tissue enhanced (liver)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (122888697 - 122922968)

Ensembl ID

ENSG00000170917  (ver. 103.38)

Orthologs

Mouse Nudt6: ENSMUSG00000050174

UniProt

P53370

neXtProt

NX_P53370

Human splice variants
Mouse splice variants

Protein structure