DNAJC24

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]). [supplied by OMIM, Mar 2008]

Description

DnaJ heat shock protein family (Hsp40) member C24

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (31369840 - 31432835)

Ensembl ID

ENSG00000170946  (ver. 103.38)

Orthologs

Mouse Dnajc24: ENSMUSG00000027166

UniProt

Q6P3W2

neXtProt

NX_Q6P3W2

Human splice variants
Mouse splice variants

Protein structure