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Cell line expression
Protein structure
PRNP
Prion proteinAltPrP, CD230, CJD, GSS, PRIP, PRP
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-32202 |
2 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| Proteintech Group | 12555-1-AP |
2 references | Polyclonal |
WB
EL
IP
IHC
FC
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| antibodies-online | ABIN2494987 |
Polyclonal |
WB
ICC
IHC
FC
|
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| OriGene | TA300958 |
1 references | Monoclonal |
WB
IHC
FC
|
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| NovoPro Bioscience Inc. | 114226 |
Polyclonal |
WB
EL
IP
IHC
FC
|
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