TLN2

This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Description

Talin 2

Tissue specificity

Tissue enhanced (kidney)

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (62390526 - 62844631)

Ensembl ID

ENSG00000171914  (ver. 103.38)

Orthologs

Mouse Tln2: ENSMUSG00000052698

UniProt

Q9Y4G6

neXtProt

NX_Q9Y4G6

Human splice variants
Mouse splice variants

Protein structure