Tissue expression
Cell line expression
Protein structure
PDZD3
PDZ domain containing 3FLJ22756, IKEPP, PDZK2
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]). [supplied by OMIM, Mar 2008]
Top validated antibodies |
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Novus Biologicals | NB400-150 | 1 references | Polyclonal |
WB
ICC
IHC
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Invitrogen Antibodies | PA3-16819 | 2 references | Polyclonal |
WB
IHC |
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Proteintech Group | 18795-1-AP | Polyclonal |
WB
EL
IP
|
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NovoPro Bioscience Inc. | 113644 | Polyclonal |
WB
EL
IP
|
||
antibodies-online | ABIN152918 | 1 references | Polyclonal |
WB
IHC |
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