KLHL6

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Description

Kelch like family member 6

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Plasma membrane, Microtubules, Mitotic spindle, Centriolar satellite

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

3 (183487551 - 183555706)

Ensembl ID

ENSG00000172578  (ver. 103.38)

Orthologs

Mouse Klhl6: ENSMUSG00000043008

UniProt

Q8WZ60

neXtProt

NX_Q8WZ60

Human splice variants
Mouse splice variants

Protein structure