CES4A

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

Description

Carboxylesterase 4A

Tissue specificity

Tissue enhanced (fallopian tube, skin)

Subcell location

Cytosol

Predicted location

Intracellular, Secreted - unknown location

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

16 (66988589 - 67009758)

Ensembl ID

ENSG00000172824  (ver. 103.38)

Orthologs

Mouse Ces4a: ENSMUSG00000060560

UniProt

Q5XG92

neXtProt

NX_Q5XG92

Human splice variants
Mouse splice variants

Protein structure