CES3

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined. [provided by RefSeq, Jun 2010]

Description

Carboxylesterase 3

Tissue specificity

Tissue enhanced (intestine, liver, skeletal muscle)

Subcell location

Nuclear membrane, Endoplasmic reticulum

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (66961245 - 66975149)

Ensembl ID

ENSG00000172828  (ver. 103.38)

Orthologs

-

UniProt

Q6UWW8

neXtProt

NX_Q6UWW8

Human splice variants

Protein structure