ADCY5

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Description

Adenylate cyclase 5

Tissue specificity

Tissue enhanced (brain, heart muscle)

Subcell location

Intermediate filaments

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (123282296 - 123449090)

Ensembl ID

ENSG00000173175  (ver. 103.38)

Orthologs

Mouse Adcy5: ENSMUSG00000022840

UniProt

O95622

neXtProt

NX_O95622

Human splice variants
Mouse splice variants

Protein structure