GPR151

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Description

G protein-coupled receptor 151

Tissue specificity

Tissue enriched (brain)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

5 (146513103 - 146516190)

Ensembl ID

ENSG00000173250  (ver. 103.38)

Orthologs

Mouse Gpr151: ENSMUSG00000042816

UniProt

Q8TDV0

neXtProt

NX_Q8TDV0

Human splice variants
Mouse splice variants

Protein structure