AGR3

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]

Description

Anterior gradient 3, protein disulphide isomerase family member

Tissue specificity

Tissue enhanced (fallopian tube, intestine, lung)

Subcell location

Endoplasmic reticulum, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (16859412 - 16881987)

Ensembl ID

ENSG00000173467  (ver. 103.38)

Orthologs

Mouse Agr3: ENSMUSG00000036231

UniProt

Q8TD06

neXtProt

NX_Q8TD06

Human splice variants
Mouse splice variants

Protein structure