Tissue expression
Cell line expression
Protein structure
RAG2
Recombination activating 2This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 11825-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | 11825-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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NovoPro Bioscience Inc. | 114525 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
||
FineTest Biotech | FNab07089 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
||
Biorbyt | orb630494 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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Supportive data in Antibodypedia
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Recommended by provider