Tissue expression
Cell line expression
Protein structure
SART1
Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNPAra1, HAF, SNRNP110, Snu66
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-56663 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
|
NSJ Bioreagents | RQ7452 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Proteintech Group | 22675-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP |
|
GeneTex | GTX103371 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Biorbyt | orb1402181 | Polyclonal |
WB
EL
ICC
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider