MUC20

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]

Description

Mucin 20, cell surface associated

Tissue specificity

Tissue enhanced (esophagus, kidney)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (195720884 - 195741123)

Ensembl ID

ENSG00000176945  (ver. 103.38)

Orthologs

Mouse Muc20: ENSMUSG00000035638

UniProt

Q8N307

neXtProt

NX_Q8N307

Human splice variants
Mouse splice variants

Protein structure