SCN4B

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene. [provided by RefSeq, Mar 2009]

Description

Sodium voltage-gated channel beta subunit 4

Tissue specificity

Tissue enhanced (brain, tongue)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

11 (118133377 - 118152888)

Ensembl ID

ENSG00000177098  (ver. 103.38)

Orthologs

Mouse Scn4b: ENSMUSG00000046480

UniProt

Q8IWT1

neXtProt

NX_Q8IWT1

Human splice variants
Mouse splice variants

Protein structure