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Protein structure
NR2C2
Nuclear receptor subfamily 2 group C member 2hTAK1, TAK1, TR2R1, TR4
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Top validated antibodies |
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| LSBio |  LS-C340217 |
Monoclonal |
WB
IHC
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| Invitrogen Antibodies | MA5-26855 |
2 references | Monoclonal |
WB
IHC
OA
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| Novus Biologicals | PP-H0107B-00 |
1 references | Monoclonal |
WB
EL
IP
IHC
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| R&D Systems | PP-H0107B-00 |
1 references | Monoclonal |
WB
EL
IP
IHC
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| NSJ Bioreagents | RQ8296 |
Polyclonal |
WB
EL
IHC
FC
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