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IMPDH2
Inosine monophosphate dehydrogenase 2This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  12948-1-AP |
50 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN395050 |
5 references | Monoclonal |
WB
EL
IP
IHC
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| Atlas Antibodies | HPA001400 |
6 references | Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | 12948-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | NBP2-75541 |
Monoclonal |
WB
ICC
IP
IHC
FC
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