SHISA3

This gene encodes a single-transmembrane protein which is one of nine members of a family of transmembrane adaptors that modulate both WNT and FGF signaling by blocking the maturation and transport of their receptors to the cell surface. Members of this family contain an N-terminal cysteine-rich domain with a distinct cysteine pattern, a single transmembrane domain, and a C-terminal proline-rich, low complexity region. The encoded protein acts as a tumor suppressor by accelerating beta-catenin degradation. [provided by RefSeq, Jul 2017]

Description

Shisa family member 3

Tissue specificity

Tissue enhanced (heart muscle, kidney)

Subcell location

Lipid droplets, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

4 (42397488 - 42402487)

Ensembl ID

ENSG00000178343  (ver. 103.38)

Orthologs

Mouse Shisa3: ENSMUSG00000050010

UniProt

A0PJX4

neXtProt

NX_A0PJX4

Human splice variants
Mouse splice variants

Protein structure