CDH5

This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

Description

Cadherin 5

Tissue specificity

Tissue enhanced (placenta)

Subcell location

Nucleoplasm, Nuclear membrane, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (66366622 - 66404784)

Ensembl ID

ENSG00000179776  (ver. 103.38)

Orthologs

Mouse Cdh5: ENSMUSG00000031871

UniProt

P33151

neXtProt

NX_P33151

Human splice variants
Mouse splice variants

Protein structure