CITED4

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

Description

Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

1 (40861054 - 40862363)

Ensembl ID

ENSG00000179862  (ver. 103.38)

Orthologs

Mouse Cited4: ENSMUSG00000070803

UniProt

Q96RK1

neXtProt

NX_Q96RK1

Human splice variants
Mouse splice variants

Protein structure