MAP3K15

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

Description

Mitogen-activated protein kinase kinase kinase 15

Tissue specificity

Group enriched (adrenal gland, choroid plexus)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

X (19360056 - 19515261)

Ensembl ID

ENSG00000180815  (ver. 103.38)

Orthologs

Mouse Map3k15: ENSMUSG00000031303

UniProt

Q6ZN16

neXtProt

NX_Q6ZN16

Human splice variants
Mouse splice variants

Protein structure