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SETD2
SET domain containing 2, histone lysine methyltransferaseFLJ23184, HIF-1, HYPB, KIAA1732, KMT3A
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Top validated antibodies |
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| Proteintech Group |  55377-1-AP |
5 references | Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-34934 |
3 references | Polyclonal |
WB
ICC
IHC
OA
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| Bioworld Technology, Inc | BS7519 |
Polyclonal |
WB
ICC
IP
IHC
ChIP
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| LSBio | LS-C339155 |
Monoclonal |
WB
IHC
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| Antibodies.com | A30718 |
Polyclonal |
WB
ICC
IP
IHC
ChIP
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