Tissue expression
Cell line expression
Protein structure
PRKAG1
Protein kinase AMP-activated non-catalytic subunit gamma 1The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN1724932 | 2 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
Invitrogen Antibodies | MA5-31866 | Monoclonal |
WB
EL
ICC
IHC
FC
OA |
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Proteintech Group | 10290-1-AP | 3 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Novus Biologicals | NBP2-37285 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
LSBio | LS-B15606 | Monoclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider