UNC5C

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Description

Unc-5 netrin receptor C

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (95162504 - 95549206)

Ensembl ID

ENSG00000182168  (ver. 103.38)

Orthologs

Mouse Unc5c: ENSMUSG00000059921

UniProt

O95185

neXtProt

NX_O95185

Human splice variants
Mouse splice variants

Protein structure