LDOC1

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

Description

LDOC1 regulator of NFKB signaling

Tissue specificity

Tissue enhanced (pituitary gland)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (141111605 - 141177129)

Ensembl ID

ENSG00000182195  (ver. 103.38)

Orthologs

Mouse Ldoc1: ENSMUSG00000057615

UniProt

O95751

neXtProt

NX_O95751

Human splice variants
Mouse splice variants

Protein structure