KCNK4

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Description

Potassium two pore domain channel subfamily K member 4

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Chromosome

11 (64291302 - 64300031)

Ensembl ID

ENSG00000182450  (ver. 103.38)

Orthologs

Mouse Kcnk4: ENSMUSG00000024957

UniProt

Q9NYG8

neXtProt

NX_Q9NYG8

Human splice variants
Mouse splice variants

Protein structure