Tissue expression
Cell line expression
Protein structure
LIMK2
LIM domain kinase 2There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-37630 | 2 references | Polyclonal |
WB
ICC
IHC
OA |
|
GeneTex | GTX50188 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
OriGene | TA590208 | Polyclonal |
WB
EL
ICC
IHC |
||
LSBio | LS-C793402 | Polyclonal |
WB
EL
ICC
IHC |
||
Novus Biologicals | NBP1-85783 | 2 references | Polyclonal |
WB
ICC
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider