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SOCS3
Suppressor of cytokine signaling 3CIS3, Cish3, SOCS-3, SSI-3
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  14025-1-AP |
37 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| OriGene | TA502991 |
1 references | Monoclonal |
WB
ICC
IHC
FC
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| GeneTex | GTX23693 |
1 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | CF502921 |
Monoclonal |
WB
ICC
IHC
FC
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| Abnova Corporation | H00009021-M02 |
1 references | Monoclonal |
EL
ICC
IHC
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