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IKZF1
IKAROS family zinc finger 1hIk-1, Hs.54452, IKAROS, LyF-1, PPP1R92, ZNFN1A1
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Top validated antibodies |
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| Proteintech Group |  12016-1-AP |
8 references | Polyclonal |
WB
EL
IP
IHC
|
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| Novus Biologicals | AF4984 |
1 references | Polyclonal |
WB
ICC
FC
ChIP
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| R&D Systems | AF4984 |
1 references | Polyclonal |
WB
ICC
FC
ChIP
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| antibodies-online | ABIN952880 |
5 references | Polyclonal |
WB
IHC
FC
|
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| GeneTex | GTX129438 |
2 references | Polyclonal |
WB
IP
ChIP
|
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