FCAR

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Fc fragment of IgA receptor

Tissue specificity

Group enriched (bone marrow, lung, lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (54874235 - 54891420)

Ensembl ID

ENSG00000186431  (ver. 103.38)

Orthologs

-

UniProt

P24071

neXtProt

NX_P24071

Human splice variants

Protein structure