SPOCK3

This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Description

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3

Tissue specificity

Tissue enhanced (brain, parathyroid gland, prostate)

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (166733384 - 167234796)

Ensembl ID

ENSG00000196104  (ver. 103.38)

Orthologs

Mouse Spock3: ENSMUSG00000054162

UniProt

Q9BQ16

neXtProt

NX_Q9BQ16

Human splice variants
Mouse splice variants

Protein structure