Tissue expression
Cell line expression
Protein structure
AKR1C3
Aldo-keto reductase family 1 member C3DDX, HAKRB, HSD17B5, KIAA0119, PGFS
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Top validated antibodies |
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Invitrogen Antibodies | PA5-28065 | 1 references | Polyclonal |
WB
ICC
IP
IHC
OA
|
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Proteintech Group | 11194-1-AP | 7 references | Polyclonal |
WB
EL
IP
IHC |
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LSBio | LS-C375177 | Polyclonal |
WB
EL
IP
IHC |
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Cusabio Biotech Co., Ltd | CSB-PA001544ESR1HU | 1 references | Polyclonal |
WB
EL
IP
IHC |
|
GeneTex | GTX104627 | Polyclonal |
WB
ICC
IP
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider