ADH1B

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

Alcohol dehydrogenase 1B (class I), beta polypeptide

Tissue specificity

Tissue enhanced (adipose tissue, liver)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (99304971 - 99352760)

Ensembl ID

ENSG00000196616  (ver. 103.38)

Orthologs

-

UniProt

P00325

neXtProt

NX_P00325

Human splice variants

Protein structure