VKORC1L1

This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

Description

Vitamin K epoxide reductase complex subunit 1 like 1

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (65873074 - 65959563)

Ensembl ID

ENSG00000196715  (ver. 103.38)

Orthologs

Mouse Vkorc1l1: ENSMUSG00000066735

UniProt

Q8N0U8

neXtProt

NX_Q8N0U8

Human splice variants
Mouse splice variants

Protein structure