ADH4

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Description

Alcohol dehydrogenase 4 (class II), pi polypeptide

Tissue specificity

Tissue enriched (liver)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (99123657 - 99157792)

Ensembl ID

ENSG00000198099  (ver. 103.38)

Orthologs

Mouse Adh4: ENSMUSG00000037797

UniProt

P08319

neXtProt

NX_P08319

Human splice variants
Mouse splice variants

Protein structure