LPAR1

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

Description

Lysophosphatidic acid receptor 1

Tissue specificity

Group enriched (brain, choroid plexus)

Subcell location

Nuclear speckles, Plasma membrane

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (110873263 - 111038458)

Ensembl ID

ENSG00000198121  (ver. 103.38)

Orthologs

Mouse Lpar1: ENSMUSG00000038668

UniProt

Q92633

neXtProt

NX_Q92633

Human splice variants
Mouse splice variants

Protein structure