Tissue expression
Cell line expression
Protein structure
ABCA4
ATP binding cassette subfamily A member 4ABCR, ARMD2, CORD3, FFM, RP19, STGD, STGD1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, and the gene product mediates transport of an essental molecule, all-trans-retinal aldehyde (atRAL), across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq, Sep 2019]
Top validated antibodies |
|||||
Novus Biologicals | NBP1-30032 | 4 references | Monoclonal |
WB
ICC
IHC
|
|
Invitrogen Antibodies | PA5-87983 | 1 references | Polyclonal |
WB
ICC
OA
|
|
antibodies-online | ABIN371821 | 4 references | Monoclonal |
WB
ICC
IHC
|
|
Biorbyt | orb2212609 | Polyclonal |
WB
EL
ICC
IHC |
||
FineTest Biotech | FNab09922 | Polyclonal |
WB
EL
ICC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider