NOS1AP

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

Description

Nitric oxide synthase 1 adaptor protein

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (162069691 - 162370475)

Ensembl ID

ENSG00000198929  (ver. 103.38)

Orthologs

Mouse Nos1ap: ENSMUSG00000038473

UniProt

O75052

neXtProt

NX_O75052

Human splice variants
Mouse splice variants

Protein structure