Tissue expression
Cell line expression
Protein structure
CR1
Complement C3b/C4b receptor 1 (Knops blood group)CD35, KN
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
Top validated antibodies |
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Novus Biologicals | NBP2-29460 | 5 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | MA5-13122 | 3 references | Monoclonal |
ICC
IHC
FC
OA |
|
NovoPro Bioscience Inc. | 131582 | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
||
Abgent | AH10160 | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
||
OriGene | AM50104PU-S | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Supportive data in Antibodypedia
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider