CCHCR1

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]

Description

Coiled-coil alpha-helical rod protein 1

Tissue specificity

Tissue enriched (testis)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (31142439 - 31158238)

Ensembl ID

ENSG00000204536  (ver. 103.38)

Orthologs

Mouse Cchcr1: ENSMUSG00000040312

UniProt

Q8TD31

neXtProt

NX_Q8TD31

Human splice variants
Mouse splice variants

Protein structure