Tissue expression
Cell line expression
Protein structure
HLA-F
Major histocompatibility complex, class I, FThis gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 14670-1-AP | 10 references | Polyclonal |
WB
EL
IHC
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Biorbyt | orb461041 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-100066 | Polyclonal |
WB
ICC
IHC
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LSBio | LS-C802710 | Polyclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | NBP1-59537 | Polyclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider