FBXO16

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Description

F-box protein 16

Tissue specificity

Tissue enhanced (epididymis, pituitary gland)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

8 (28348287 - 28490278)

Ensembl ID

ENSG00000214050  (ver. 103.38)

Orthologs

Mouse Fbxo16: ENSMUSG00000034532

UniProt

Q8IX29

neXtProt

NX_Q8IX29

Human splice variants
Mouse splice variants

Protein structure