FNIP1

This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

Description

Folliculin interacting protein 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

5 (131641714 - 131797063)

Ensembl ID

ENSG00000217128  (ver. 103.38)

Orthologs

Mouse Fnip1: ENSMUSG00000035992

UniProt

Q8TF40

neXtProt

NX_Q8TF40

Human splice variants
Mouse splice variants

Protein structure