HEPN1

This gene is expressed predominantly in the liver. Transient transfection studies show the expression of this gene significantly inhibits cell growth, suggesting a role for this gene in apoptosis. Expression of this gene is down-regulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). This gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand. [provided by RefSeq, Aug 2020]

Description

Hepatocellular carcinoma, down-regulated 1

Tissue specificity

Tissue enhanced (adipose tissue, brain, liver)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

11 (124919244 - 124920677)

Ensembl ID

ENSG00000221932  (ver. 103.38)

Orthologs

-

UniProt

Q6WQI6

neXtProt

NX_Q6WQI6

Human splice variants

Protein structure