PGA4

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

Description

Pepsinogen A4

Tissue specificity

Tissue enriched (stomach)

Predicted location

Intracellular, Secreted to digestive system

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

11 (61222349 - 61231694)

Ensembl ID

ENSG00000229183  (ver. 103.38)

Orthologs

-

UniProt

P0DJD7

neXtProt

NX_P0DJD7

Human splice variants

Protein structure