PRPS1L1

This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008]

Description

Phosphoribosyl pyrophosphate synthetase 1 like 1

Tissue specificity

Tissue enriched (testis)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

7 (18026770 - 18027846)

Ensembl ID

ENSG00000229937  (ver. 103.38)

Orthologs

Mouse Prps1l1: ENSMUSG00000092305

UniProt

P21108

neXtProt

NX_P21108

Human splice variants
Mouse splice variants

Protein structure